the 19-year-old England international, who is in talks to join Real Madrid this summer, took his season tally to 13 goals in all competitions.
Karim Adeyemi also scored twice as well as missing a late penalty for Edin Terzic's side.
Sebastien Haller and Donyell Malen completed the scoring.
The defeat leaves Wolfsburg in seventh place, two points outside the European qualification places.
After surrendering their lead at the top last weekend following a draw at relegation battlers VfL Bochum, Dortmund needed a response to keep up the pressure on Bayern, who opened up a four-point gap with victory over Werder Bremen on Saturday